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SLAS2020 Short Courses

Genome Editing Applications in Drug Discovery and Target Validation

Genome editing tools such as CRISPR-Cas9 are reshaping what is possible within the biological sciences. This course will introduce the possibilities of what can be achieved with genome editing, the current limitations, and the fundamentals of how to apply these technologies to enhance the pursuit of targets and therapeutics.

Who Should Attend

  • Assay and HTS biologists
  • Those interested in drug discovery technology
  • Scientists working on functional genomics and genetic screens
  • Those wanting to learn the basics of CRISPR/Cas9 technology and how it can be practically applied

Course Benefits

  • Up-to-date information on the tools, methods and applications of genome editing
  • Workflows for typical experiments and practical use cases
  • Case studies

Course Topics

  • Genome engineering concepts
  • Gene editing in 2020: Workflows to creating knockouts and knocking cell lines
  • CRISPR-Cas9 and beyond – tools of the trade
  • Applications of genome editing in functional genomics
  • Practical guides to using genome editing tools in genetic screens

Instructors

Scott T. Younger

Scott T. Younger
Children’s Research Institute, Children’s Mercy Kansas City

Scott Younger, Ph.D., is the Director of Disease Gene Engineering within the Center for Pediatric Genomic Medicine at Children's Mercy Kansas City. His laboratory is focused on dissecting the molecular mechanisms through which rare genetic variants identified in patients at Children's Mercy lead to disease. Younger joined Children's Mercy from the Broad Institute of MIT and Harvard where his group worked on the development of new methodologies to expand the utility of CRISPR-based genetic screens. Prior to working at the Broad Institute, he completed his postdoctoral studies at Harvard University as an American Cancer Society Fellow. He holds a Ph.D. in cell and molecular biology from UT Southwestern Medical Center. He also received an M.S. in biotechnology from the University of Texas at San Antonio and a B.S.I. in bioinformatics from Baylor University.

Samuel A. Hasson

Samuel A. Hasson, Ph.D.
Amgen

Sam Hasson, Ph.D., is a Senior Scientist and lab head in Amgen Neuroscience (Cambridge, Massachusetts). His lab focuses on the deconvolution of human genetics for novel target selection and employs genome editing technologies to enable this process. A major goal of his work is to identify modulators of complex neuroimmune phenotypes utilizing innovative assay design strategies such as high content screening. Prior to joining Amgen Neuroscience in 2018, Sam led a group in Pfizer Neuroscience. As a postdoc, Sam trained with Richard Youle and Jim Inglese at the National Institutes of Health.


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